Publications

HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZ.

Miyajima C, Hayakawa Y, Inoue Y, Nagasaka M, Hayashi H.

Pharmaceuticals, 2022, 15, 1015.

 

The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.

Nagasaka M, Inoue Y, Yoshida M, Miyajima C, Morishita D, Tokugawa M, Nakamoto H, Sugano M, Ohoka N Hayashi H.

FEBS Lett., 2022, 596, 465-478.

 

Periplocin and cardiac glycosides suppress the unfolded protein response.

Tokugawa M, Inoue Y, Ishiuchi K, Kujirai C, Matsuno M, Ri M, Itoh Y, Miyajima C, Morishita D, Ohoka N, Iida S, Mizukami H, Makino T, Hayashi H.

Sci. Rep., 2021, 11, 9528.

 

Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.

Nishikawa S, Inoue Y, Hori Y, Miyajima C, Morishita D, Ohoka N, Hida S, Makino T, Hayashi H.

Antioxidants, 2020, 9, 842.

 

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.

Miyajima C, Kawarada Y, Inoue Y, Suzuki C, Mitamura K, Morishita D, Ohoka N, Imamura T, Hayashi H.

Cells, 2020, 9, 171.

 

A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone.

Kushioka J, Kaito T, Okada R, Ishiguro H, Bai Z, Kodama J, Chijimatsu R, Pye M, Narimatsu M, Wrana JL, Inoue Y, Ninomiya H, Yamamoto S, Saitou H, Yoshikawa H, Imamura T.

Bone Res., 2020, 8, 41.

 

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol.

Sumito N, Koeda S, Umezawa N, Inoue Y, Tsukiji S, Higuchi T, Mizuno T.

Bioconjug. Chem., 2020, 31, 821-833.

 

The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21.

Fukuura K, Inoue Y, Miyajima C, Watanabe S, Tokugawa M, Morishita D, Ohoka N, Komada M, Hayashi H.

J. Biol. Chem., 2019, 294, 16429-16439.

 

Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation.

Nisjikawa S, Itoh Y, Tokugawa M, Inoue Y, Nakashima KI, Hori Y, Miyajima C, Yoshida K, Morishita D, Ohoka N, Inoue M, Mizukami H, Makino T, Hayashi H.

Molecules, 2019, 24, 3110.

 

Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition.

Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M.

Cancer Res., 2019, 79, 2821-2838.

 

TRB1 negatively regulates gluconeogenesis by suppressing the transcriptional activity of FOXO1.

Tsuzuki K, Itoh Y, Inoue Y, Hayashi H.

FEBS Lett., 2019, 593, 369-380.

 
Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc.

Nagasaka M, Tsuzuki K, Ozeki Y,  Tokugawa M, Ohoka N, Inoue Y, Hayashi H.

Biol. Pharm. Bull., 2019, 42, 481-488.

 

An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity.

Ieda N, Itoh K, Inoue Y, Izumiya Y, Kawaguchi M, Miyata N, Nakagawa H.

Bioorg. Med. Chem. Lett., 2019, 29, 353-356.

 

Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway.

Nagasaka M, Hashimoto R, Inoue Y, Ishiuchi K, Matsuno M, Itoh Y, Tokugawa M, Ohoka N, Morishita D, Mizukami H, Makino T, Hayashi H.

Molecules, 2018, 23, 1394.

 

The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress.

Inoue Y, Kawachi S, Ohkubo T, Nagasaka M, Ito S, Fukuura K, Itoh Y, Ohoka N, Morishita D, Hayashi H.

FEBS Lett., 2017, 591, 3682-3691.

 

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription.

Kawarada Y, Inoue Y, Kawasaki F, Fukuura K, Sato K, Tanaka T, Itoh Y, Hayashi H.

Sci. Rep., 2016, 6, 35483.

 

Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity.

Nakashima K, Tanabe H, Fujii-Kuriyama Y, Hayashi H, Inoue M.

J. Nat. Med., 2016, 70, 476-482.

 

Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer.

Inoue Y, Itoh Y, Sato K, Kawasaki F, Sumita C, Tanaka T, Morishita D, Hayashi H.

Curr. Cancer Drug Targets, 2016, 16, 110-118.

 

Tribbles-Related Protein Family Members as Regulators or Substrates of the Ubiquitin-Proteasome System in Cancer Development.

Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y.

Curr. Cancer Drug Targets, 2016, 16, 147-156.

 

Positive Regulation of Interleukin-2 Expression by a Pseudokinase, Tribbles 1, in Activated T Cells.

Miyajima C, Itoh Y, Inoue Y, Hayashi H.

Biol. Pharm. Bull., 2015, 38, 1126-1133.

 

Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of p53 through p53 deacetylation.

Miyajima C, Inoue Y, Hayashi H.

Biol. Pharm. Bull., 2015, 38, 618-624.

 

TGF-β decreases the stability of IL-18-induced IFN-γ mRNA through the expression of TGF-β-induced tristetraprolin in KG-1 cells.

Inoue Y, Abe K, Onozaki K, Hayashi H.

Biol. Pharm. Bull., 2015, 38, 536-544.

 

A novel transgenic mouse model carrying human Tribbles related protein 3 (TRB3) gene and its site specific phenotype.

Sakai Y, Fukamachi K, Futakuchi M, Miyoshi I, Tsuda H, Suzui M, Hayashi H.

Biol. Pharm. Bull., 2014, 37, 1068-1074.

 

The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor.

Suzuki H, Hatano N, Muraki Y, Itoh Y, Kimura S, Hayashi H, Onozaki K, Ohi Y, Haji A, Muraki K.

Am. J. Physiol. Cell Physiol., 2014, 307, C384-394.

 

TRPV4 partially participates in proliferation of human brain capillary endothelial cells.

Hatano N, Suzuki H, Itoh Y, Muraki K.

Life Sci., 2013, 92, 317-324.

 

Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and inhibits tenascin C-fibronectin interaction and cell motility of keratinocytes.

Itoh S, Yamaoka N, Kamoshida G, Takii T, Tsuji T, Hayashi H, Onozaki K.

Biochem. Biophys. Res. Commun., 2013, 433, 127-132.

 

Promotive effects of cell proliferation and chromosomal instability induced by tribbles-related protein 3 in mouse mammary tumor cells.

Sakai Y, Fukamachi K, Futakuchi M, Hayashi H, Suzui M.

Oncol. Rep., 2013, 30, 64-70.

 

The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis.

Imamura T, Hikita A, Inoue Y.

Breast Cancer, 2012, 19, 118-124.

 

ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo.

Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A, Yamori T.

Eur. J. Cancer, 2012, 48, 936-943.

 

Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.

Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K.

J. Biol. Chem., 2012, 287, 31962-31972.

 

Dihydrotestosterone inhibits interleukin-1α or tumor necrosis factor α-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-κB activation in rheumatoid fibroblast-like synovial cell line.

Xu J, Itoh Y, Hayashi H, Takii T, Miyazawa K, Onozaki K.

Biol. Pharm. Bull., 2011, 34, 1724-1730.

 

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T.

J. Biol. Chem., 2011, 286, 6311-6320.

 

Cigarette smoke condensate extracts augment collagen-induced arthritis in mice.

Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Takii T, Hayakawa K, Onozaki K.

Int. Immunopharmacol., 2010, 10, 1194-1199.

 

Dual mode of regulation of cell division cycle 25 A protein by TRB3.

Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.

Biol. Pharm. Bull., 2010, 33, 1112-1116.

 

Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.

Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Takayama T, Suzuki S, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Hayashi H, Ozono S, Kitagawa M, Hishida A.

Int. J. Cancer, 2010, 127, 1517-1525.

 

IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375.

Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K.

Biochem. Biophys. Res. Commun., 2010, 392, 369-372.

 

Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.

Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.

Biochem. Biophys. Res. Commun., 2010, 392, 289-294.

 

Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.

Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T.

PLoS One, 2010, 5, e13090.

 

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nakasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Inazawa J, Miyazono K, Imamura T.

J. Biol. Chem., 2009, 284, 3334-3344.

 

Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate.

Hatano N, Itoh Y, Muraki K.

Life Sci., 2009, 85, 808-814.

 

An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes.

Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.

Am. J. Physiol. Cell Physiol., 2009, 297, C1082-1090.

 

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.

Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J.

Sci. Signal., 2009, 2, ra66.

 

Gene expression profiling identifies a role for CHOP during inhibition of the mitochondrial respiratory chain.

Ishikawa F, Akimoto T, Yamamoto H, Araki Y, Yoshie T, Mori K, Hayashi H, Nose K, Shibanuma M.

J. Biochem., 2009, 146, 123-132.

 

The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.

Ohoka N, Kato S, Takahashi Y, Hayashi H, Sato R.

Mol. Endocrinol., 2009, 23, 759-771.

 

Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells.

Fukunaga E, Komiya S, Horiguchi K, Goto K, Saitoh M, Miyazawa K, Koinuma D, Hanyu A, Imamura T.

J. Biol. Chem., 2008, 283, 35660-35667.

 

Regulation of TGF-beta family signaling by E3 ubiquitin ligases.

Inoue Y, Imamura T.

Cancer Sci., 2008, 99, 2107-2112.

 

Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition.

Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H, Taya Y.

Cancer Res., 2008, 68, 5104-5112.

 

Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.

Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.

J. Interferon Cytokine Res., 2008, 28, 509-521.

 

TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity.

Takahashi Y, Ohoka N, Hayashi H, Sato R.

J. Lipid Res., 2008, 49, 880-92.

 

Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375.

Arakawa T, Yamamura T, Hattori T, Hayashi H, Mori A, Yoshida A, Uchida C, Kitagawa M, Onozaki K.

Int. Immunopharmacol., 2008, 8, 80-89.

 

The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cells.

Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.

J. Leukoc. Biol., 2008, 83, 190-199.

 

Phosphorylation of pRB at Ser612 by Chk1/2 leads to a complex between pRB and E2F-1 after DNA damage.

Inoue Y, Kitagawa M, Taya Y.

EMBO J., 2007, 26, 2083-2093.

 

Smad3 is acetylated by p300/CBP to regulate its transactivation activity.

Inoue Y, Itoh Y, Abe K, Okamoto T, Daitoku H, Fukamizu A, Onozaki K, Hayashi H.

Oncogene, 2007, 26, 500-508.

 

Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion.

Ohoka N, Hattori T, Kitagawa M, Onozaki K, Hayashi H.

J. Biol. Chem., 2007, 282, 35687-35694.

 

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death.

Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H.

EMBO J., 2005, 24, 1243-1255.

 

The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling.

Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL, Falb D.

Cell, 1997, 89, 1165-1173.