Publications

Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression via its transcription, translation and proteasomal degradation.

Tokugawa M, Inoue Y, Aoki H, Miyajima C, Ishiuchi K, Tsurumi K, Kujirai C, Morishita D, Matsuno M, Mizukami H, Ri M, Iida S, Makino T, Aoyama M, Hayashi H.

J Biochem, 2024, 175, 253-263.

Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats.

Takeshita S, Kakita H, Nakamura N, Mori M, Toriuchi K, Aoki H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.

Exp Neurol, 2024, 377, 114781.

Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.

Yamamura A, Fujiwara M, Kawade A, Amano T, Hossain A, Nayeem MJ, Kondo R, Suzuki Y, Inoue Y, Hayashi H, Suzuki S, Sato M, Yamamura H.

Eur J Pharmacol, 2024, 973, 176564.

Chem Commun, 2024, 60, 968-971.

Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4.

Fukuda N, Toriuchi K, Mimoto R, Aoki H, Kakita H, Suzuki Y, Takeshita S, Tamura T, Yamamura H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.

Neurochem Res, 2024, 49, 800-813.

Nagasaka M, Inoue Y, Nagao Y, Miyajima C, Morishita D, Aoki H, Aoyama M, Imamura T, Hayashi H.

Sci Rep, 2023, 13, 22877.

Design of Cell-Adhesive Shellac Derivatives and Endowment of Photoswitchable Cell-Adhesion Properties.

Sunakawa Y, Kondo M, Yamamoto Y, Inomata T, Inoue Y, Mori D, Mizuno T.

ACS Appl Bio Mater, 2023, 6, 5493-5501.

AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway.

Owaki R, Aoki H, Toriuchi K, Inoue Y, Hayashi H, Takeshita S, Kakita H, Yamada Y, Aoyama M.

Exp Cell Res, 2023, 432, 113784.

The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma Therapeutic Agent.

Izumi K, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Yamada Y, Aoyama M.

Curr Cancer Drug Targets, 2023, 23, 837-842.

Monocyte-Derived miRNA-1914-5p Attenuates IL-1β-Induced Monocyte Adhesion and Transmigration.

Toriuchi K, Kihara T, Aoki H, Kakita H, Takeshita S, Ueda H, Inoue Y, Hayashi H, Shimono Y, Yamada Y, Aoyama M.

Int J Mol Sci, 2023, 24, 2829.

The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells.

Tozaki Y, Aoki H, Kato R, Toriuchi K, Arame S, Inoue Y, Hayashi H, Kubota E, Kataoka H, Aoyama M.

Cancers, 2023, 15, 735.

Insights into Regulators of p53 Acetylation

Nagasaka M, Miyajima C, Aoki H, Aoyama M, Morishita D, Inoue Y, Hayashi H.

Cells, 2022, 11, 3825.

HMG-CoA Reductase Inhibitor Statins Activate the Transcriptional Activity of p53 by Regulating the Expression of TAZ.

Miyajima C, Hayakawa Y, Inoue Y, Nagasaka M, Hayashi H.

Pharmaceuticals, 2022, 15, 1015.

The deubiquitinating enzyme USP17 regulates c-Myc levels and controls cell proliferation and glycolysis.

Nagasaka M, Inoue Y, Yoshida M, Miyajima C, Morishita D, Tokugawa M, Nakamoto H, Sugano M, Ohoka N Hayashi H.

FEBS Lett., 2022, 596, 465-478.

Periplocin and cardiac glycosides suppress the unfolded protein response.

Tokugawa M, Inoue Y, Ishiuchi K, Kujirai C, Matsuno M, Ri M, Itoh Y, Miyajima C, Morishita D, Ohoka N, Iida S, Mizukami H, Makino T, Hayashi H.

Sci. Rep., 2021, 11, 9528.

Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway.

Nishikawa S, Inoue Y, Hori Y, Miyajima C, Morishita D, Ohoka N, Hida S, Makino T, Hayashi H.

Antioxidants, 2020, 9, 842.

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence.

Miyajima C, Kawarada Y, Inoue Y, Suzuki C, Mitamura K, Morishita D, Ohoka N, Imamura T, Hayashi H.

Cells, 2020, 9, 171.

A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone.

Kushioka J, Kaito T, Okada R, Ishiguro H, Bai Z, Kodama J, Chijimatsu R, Pye M, Narimatsu M, Wrana JL, Inoue Y, Ninomiya H, Yamamoto S, Saitou H, Yoshikawa H, Imamura T.

Bone Res., 2020, 8, 41.

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol.

Sumito N, Koeda S, Umezawa N, Inoue Y, Tsukiji S, Higuchi T, Mizuno T.

Bioconjug. Chem., 2020, 31, 821-833.

The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21.

Fukuura K, Inoue Y, Miyajima C, Watanabe S, Tokugawa M, Morishita D, Ohoka N, Komada M, Hayashi H.

J. Biol. Chem., 2019, 294, 16429-16439.

Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation.

Nisjikawa S, Itoh Y, Tokugawa M, Inoue Y, Nakashima KI, Hori Y, Miyajima C, Yoshida K, Morishita D, Ohoka N, Inoue M, Mizukami H, Makino T, Hayashi H.

Molecules, 2019, 24, 3110.

Long Noncoding RNA ELIT-1 Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition.

Sakai S, Ohhata T, Kitagawa K, Uchida C, Aoshima T, Niida H, Suzuki T, Inoue Y, Miyazawa K, Kitagawa M.

Cancer Res., 2019, 79, 2821-2838.

TRB1 negatively regulates gluconeogenesis by suppressing the transcriptional activity of FOXO1.

Tsuzuki K, Itoh Y, Inoue Y, Hayashi H.

FEBS Lett., 2019, 593, 369-380.

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc.

Nagasaka M, Tsuzuki K, Ozeki Y, Tokugawa M, Ohoka N, Inoue Y, Hayashi H.

Biol. Pharm. Bull., 2019, 42, 481-488.

An irreversible inhibitor of peptidyl-prolyl cis/trans isomerase Pin1 and evaluation of cytotoxicity.

Ieda N, Itoh K, Inoue Y, Izumiya Y, Kawaguchi M, Miyata N, Nakagawa H.

Bioorg. Med. Chem. Lett., 2019, 29, 353-356.

Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway.

Nagasaka M, Hashimoto R, Inoue Y, Ishiuchi K, Matsuno M, Itoh Y, Tokugawa M, Ohoka N, Morishita D, Mizukami H, Makino T, Hayashi H.

Molecules, 2018, 23, 1394.

The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress.

Inoue Y, Kawachi S, Ohkubo T, Nagasaka M, Ito S, Fukuura K, Itoh Y, Ohoka N, Morishita D, Hayashi H.

FEBS Lett., 2017, 591, 3682-3691.

TGF-β induces p53/Smads complex formation in the PAI-1 promoter to activate transcription.

Kawarada Y, Inoue Y, Kawasaki F, Fukuura K, Sato K, Tanaka T, Itoh Y, Hayashi H.

Sci. Rep., 2016, 6, 35483.

Atranorin and lecanoric acid antagonize TCDD-induced xenobiotic response element-driven activity, but not xenobiotic response element-independent activity.

Nakashima K, Tanabe H, Fujii-Kuriyama Y, Hayashi H, Inoue M.

J. Nat. Med., 2016, 70, 476-482.

Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer.

Inoue Y, Itoh Y, Sato K, Kawasaki F, Sumita C, Tanaka T, Morishita D, Hayashi H.

Curr. Cancer Drug Targets, 2016, 16, 110-118.

Sakai S, Miyajima C, Uchida C, Itoh Y, Hayashi H, Inoue Y.

Curr. Cancer Drug Targets, 2016, 16, 147-156.

Positive Regulation of Interleukin-2 Expression by a Pseudokinase, Tribbles 1, in Activated T Cells.

Miyajima C, Itoh Y, Inoue Y, Hayashi H.

Biol. Pharm. Bull., 2015, 38, 1126-1133.

Pseudokinase tribbles 1 (TRB1) negatively regulates tumor-suppressor activity of p53 through p53 deacetylation.

Miyajima C, Inoue Y, Hayashi H.

Biol. Pharm. Bull., 2015, 38, 618-624.

TGF-β decreases the stability of IL-18-induced IFN-γ mRNA through the expression of TGF-β-induced tristetraprolin in KG-1 cells.

Inoue Y, Abe K, Onozaki K, Hayashi H.

Biol. Pharm. Bull., 2015, 38, 536-544.

A novel transgenic mouse model carrying human Tribbles related protein 3 (TRB3) gene and its site specific phenotype.

Sakai Y, Fukamachi K, Futakuchi M, Miyoshi I, Tsuda H, Suzui M, Hayashi H.

Biol. Pharm. Bull., 2014, 37, 1068-1074.

The NADPH oxidase inhibitor diphenyleneiodonium activates the human TRPA1 nociceptor.

Suzuki H, Hatano N, Muraki Y, Itoh Y, Kimura S, Hayashi H, Onozaki K, Ohi Y, Haji A, Muraki K.

Am. J. Physiol. Cell Physiol., 2014, 307, C384-394.

TRPV4 partially participates in proliferation of human brain capillary endothelial cells.

Hatano N, Suzuki H, Itoh Y, Muraki K.

Life Sci., 2013, 92, 317-324.

Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and inhibits tenascin C-fibronectin interaction and cell motility of keratinocytes.

Itoh S, Yamaoka N, Kamoshida G, Takii T, Tsuji T, Hayashi H, Onozaki K.

Biochem. Biophys. Res. Commun., 2013, 433, 127-132.

Promotive effects of cell proliferation and chromosomal instability induced by tribbles-related protein 3 in mouse mammary tumor cells.

Sakai Y, Fukamachi K, Futakuchi M, Hayashi H, Suzui M.

Oncol. Rep., 2013, 30, 64-70.

The roles of TGF-β signaling in carcinogenesis and breast cancer metastasis.

Imamura T, Hikita A, Inoue Y.

Breast Cancer, 2012, 19, 118-124.

ZSTK474, a specific phosphatidylinositol 3-kinase inhibitor, induces G1 arrest of the cell cycle in vivo.

Dan S, Okamura M, Mukai Y, Yoshimi H, Inoue Y, Hanyu A, Sakaue-Sawano A, Imamura T, Miyawaki A, Yamori T.

Eur. J. Cancer, 2012, 48, 936-943.

Hypoxia-inducible factor-1α (HIF1α) switches on transient receptor potential ankyrin repeat 1 (TRPA1) gene expression via a hypoxia response element-like motif to modulate cytokine release.

Hatano N, Itoh Y, Suzuki H, Muraki Y, Hayashi H, Onozaki K, Wood IC, Beech DJ, Muraki K.

J. Biol. Chem., 2012, 287, 31962-31972.

Dihydrotestosterone inhibits interleukin-1α or tumor necrosis factor α-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-κB activation in rheumatoid fibroblast-like synovial cell line.

Xu J, Itoh Y, Hayashi H, Takii T, Miyazawa K, Onozaki K.

Biol. Pharm. Bull., 2011, 34, 1724-1730.

Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.

Inoue Y, Iemura S, Natsume T, Miyazawa K, Imamura T.

J. Biol. Chem., 2011, 286, 6311-6320.

Cigarette smoke condensate extracts augment collagen-induced arthritis in mice.

Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Takii T, Hayakawa K, Onozaki K.

Int. Immunopharmacol., 2010, 10, 1194-1199.

Dual mode of regulation of cell division cycle 25 A protein by TRB3.

Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.

Biol. Pharm. Bull., 2010, 33, 1112-1116.

Reduction of transforming growth factor-beta type II receptor is caused by the enhanced ubiquitin-dependent degradation in human renal cell carcinoma.

Fukasawa H, Yamamoto T, Fujigaki Y, Misaki T, Ohashi N, Takayama T, Suzuki S, Mugiya S, Oda T, Uchida C, Kitagawa K, Hattori T, Hayashi H, Ozono S, Kitagawa M, Hishida A.

Int. J. Cancer, 2010, 127, 1517-1525.

IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375.

Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K.

Biochem. Biophys. Res. Commun., 2010, 392, 369-372.

Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.

Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.

Biochem. Biophys. Res. Commun., 2010, 392, 289-294.

Mechanical stress activates Smad pathway through PKCδ to enhance interleukin-11 gene transcription in osteoblasts.

Kido S, Kuriwaka-Kido R, Umino-Miyatani Y, Endo I, Inoue D, Taniguchi H, Inoue Y, Imamura T, Matsumoto T.

PLoS One, 2010, 5, e13090.

SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

Takahata M, Inoue Y, Tsuda H, Imoto I, Koinuma D, Hayashi M, Ichikura T, Yamori T, Nakasaki K, Yoshida M, Matsuoka M, Morishita K, Yuki K, Hanyu A, Inazawa J, Miyazono K, Imamura T.

J. Biol. Chem., 2009, 284, 3334-3344.

Cardiac fibroblasts have functional TRPV4 activated by 4alpha-phorbol 12,13-didecanoate.

Hatano N, Itoh Y, Muraki K.

Life Sci., 2009, 85, 808-814.

An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes.

Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.

Am. J. Physiol. Cell Physiol., 2009, 297, C1082-1090.

Two mechanistically and temporally distinct NF-kappaB activation pathways in IL-1 signaling.

Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J.

Sci. Signal., 2009, 2, ra66.

Gene expression profiling identifies a role for CHOP during inhibition of the mitochondrial respiratory chain.

Ishikawa F, Akimoto T, Yamamoto H, Araki Y, Yoshie T, Mori K, Hayashi H, Nose K, Shibanuma M.